ZYLÖ IN THE NEWS
$1.7M NIH Grant Awarded
This award is to advance Zylö's program to treat Erectile Dysfunction patients that do not respond to PDE5 inhibitors such as Viagra....an addressable market exceeding $2B/year in the U.S. alone. Funds to be used for scale-up (with ISO-9001 and cGMP quality systems) and for IND-enabling studies so that Phase 1 human trials can begin
Zylö and Amifar forge broad-ranging partnership to take 'the Science of Beauty' to the next level
Amifar and Zylö have initiated a product development collaboration beginning with two actives and have plans to expand the list of actives over time.
Silo Pharma and Zylö form JV to develop sustained-release ketamine using Z-pod™ technology
Zylö's Z-pod™ technology advances Silo's vision of bringing ground-breaking therapeutics to patients in need.
ED paper submitted by Zylö's Dr. Draganski and his collaborators accepted by J. of Sexual Medicine
Study showing that topically applied Nitric-Oxide-releasing Z-pods™ restore sexual function in rats that have been rendered sexually dysfunctional (by cutting their cavernous nerve) is accepted and can be found via the following link:
NO-based treatments may be pivotal in the world's fight against Covid-19
GWU's Adam Friedman MD, along with collaborators, published a review article in the Journal Nitric Oxide about the mechanisms of action of NO and how it can play a key role in mitigating each step of the spiraling cascade of events from Covid-19 infection to death.
SCRA invests an additional $182,500 in COVID-related convertible note
Subsequent to the submittal of an EUA to the FDA by Zylö for a proposed NO-related treatment of COVID-19, the South Carolina Research Authority (SCRA) provided the company $182,500 of funds in the form of a convertible note.
Zylö Receives $41,000 Matching Grant from SCRA
Zylö received a $41,000 Matching Grant from SC Launch (part of SCRA) relating to Zylö's Phase 1 grant award of $225,000 from the NIH to explore the effects of Nitric Oxide-releasing Z-pods™ combined with sildenafil/Viagra for the treatment of Erectile Dysfunction secondary to radical prostatectomy in a rat model.
Zylö Expands Partnership With HOTH Therapeutics
HOTH announces a strategic equity investment in Zylö in an expansion of the HOTH-Zylö partnership involving Anandamide-loaded Z-pods™ to treat cutaneous lupus.
Zylö Receives $225,000 NIH Grant
Zylö receives grant to further develop its proprietary nitric-oxide topical delivery system to treat topically erectile dysfunction in patients refractory to oral PDE5 inhibitors (like Viagra).
Zylö Closes $4 Million Series A Preferred Round
VentureSouth leads over-subscribed round, with the following groups also playing an important role: NY Angels, ASAP, SCRA, Boston Harbor Angels, Chemist Angel Network.
Adam Friedman MD Presents Keynote Speech
Zylö's key scientific advisor, Adam Friedman MD, served as a keynote speaker at the Dermatology Update 2019 Fall Meeting in Toronto on November 7.
Zylö Receives SCRA Investment
SCRA announces a $200,000 SC Launch, Inc. investment in Zylö Therapeutics. The life sciences company, located in Greenville, was accepted into SCRA’s entrepreneurial program, SC Launch, in June 2018.
Dr. Adam Friedman Likes Longer-Lasting Lidocaine (aka the Patchless Patch™)
In this MDedge.com podcast, Dr. Adam Friedman responds to "What is 'nanodermatology' and what is on the horizon?" and speaks to the advantages of lidocaine-loaded Z-pods™.
ZYLÖ IN THE NEWS: 2018 & PRIOR
"THE THERAPEUTIC POTENTIAL OF CANNABINOIDS IN DERMATOLOGY"
Dr, Adam Friedman discusses the wide-ranging utility of cannabinoids to treat inflammatory and neoplastic skin conditions
ENDOCANNABINOID-LOADED Z-PODS SHOW EFFICACY AGAINST LUPUS
Dr. Adam Friedman directed session F003 ‘Treating Tumors and Inflammatory Skin Diseases with Immunomodulators and Biologics’ at the American Academy of Dermatology on February 16, 2018. During the session, he presented the lecture “The Potential of Cannabinoids for the Treatment of Inflammatory and Neoplastic Diseases of the Skin” which included exciting new data demonstrating that endocannabinoid-loaded Z-pods significantly reduce the size and severity of lesions in a cutaneous lupus animal model.
"LESS IS MORE: NANOTECHNOLOGY ENHANCES ANTIFUNGAL’S EFFICACY"
Heidi Splete summarizes recent findings that indicate Zylö’s Nitric Oxide-releasing Z-pods™ can enhance efficacy of both efinaconazole (Jublia) and terbinafine (Lamisil) in the treatment of fungal infections. In earlier studies, treatment with these Z-pods™ was demonstrated to be more efficacious than terbinafine on a head-to-head stand-alone basis.
"NITRIC OXIDE-RELEASING MICROPARTICLES AS A POTENT ANTIMICROBIAL THERAPEUTIC AGAINST CHRONIC RHINOSINUSITIS BACTERIAL ISOLATES"
A collaborative effort led by Waleed Abuzeid MD, Assistant Professor at Montefiore Hospital, and Joel Friedman MD PhD, Professor at Einstein College of Medicine, yielded early success in a promising new approach for chronic rhino sinusitis using Zylö’s Z-pods™.
“WILL MEDTECH DRIVE THE NEXT SOUTHEASTERN U.S. INDUSTRIAL REVOLUTION?”
Paul Snyder of Write2Market interviews Zylö CEO Scott Pancoast about the resurgence of the Southeast in an article with the subtitle, "One South Carolina startup relies on the Southeastern U.S. history of engineering innovation, new infrastructure and quality of life to drive drug delivery innovation through nanoparticles."
ENDOCANNABINOID-LOADED Z-PODS TO TREAT LUPUS
At the American Academy of Dermatology 2018, Dr. Adam Friedman is interviewed (and videotaped) by Elizabeth Mechcatie from Dermatology News about using cannabinoids to treat a variety of diseases and conditions and specifically about using Zylö’s Z-pods™—combined with AEA—to treat the cutaneous manifestations of lupus
CANNABINOIDS TO TREAT PAIN
Adam Friedman MD weighs in on the pros and cons of using cannabis in skin cremes to relieve pain in the article, “Beauty Not As Pain, But A Remedy For It” in the BENEATH THE SURFACE section of Beauty Independent, December 21, 2017.
CANNABINOIDS TO TREAT INFLAMMATORY SKIN CONDITIONS
Adam Friedman MD and George Han MD PhD spoke with Dermatology World Meeting News at the AAD Meeting, February 2018. to discuss some of the recent advances in treating tumors and inflammatory skin diseases and what could be coming next, including the potential of cannabinoids to treat various diseases and conditions.
CANNABIS-INFUSED BEAUTY PRODUCTS
Adam Friedman MD is interviewed by Health.com about possible skin-related benefits of CBD in an online article titled, “Do Cannabis-Infused Beauty Products Actually Work? Everything You Need to Know” by Lisa Desantis, January 26, 2018
"PROMISE OF NITRIC OXIDE FOR SKIN AND SOFT TISSUE INFECTIONS"
In this Dermatology Advisor article, Adam Friedman MD, FAAD, and Leon Kircik, MD discuss the wide-ranging potential of Nitric Oxide in the treatment of infections (including multi-drug resistant infections) and the advantages of a particle delivery system that provides steady and constant penetration into the affected area.
"HOW THE LEGALIZATION OF MARIJUANA AFFECTS YOUR SKIN"
In this Elle Magazine article, Dr. Adam Friedman discusses the numerous potential applications for CBD and other cannabis derivatives for the treatment of skin conditions, including chronic inflammation and debilitating itch or pain.
"TOPICAL CURCUMIN TREATS ERECTILE DYSFUNCTION" ESSAY WINS TOP PRIZE
The Zylö team wins top prize for Best Male Sexual Health Essay at the 18th Annual Fall Scientific Meeting of the Sexual Medicine Society of North America in October 2017 (San Antonio): ”Topical Abdominal Application of Curcumin-Loaded Nanoparticles Protects Erectile Function in a Rat Model of Type 2 Diabetes” by A Draganski, et al.
“THERAPEUTIC FOCUS: FUNGAL INFECTIONS: NITRIC OXIDE-RELEASING NANOPARTICLES FOR SKIN INFECTIONS”
In the September 2017 issue of Practicing Dermatology, Dr. Adam Friedman discusses his work demonstrating that topically applied nitric oxide-releasing Z-pods are a viable treatment for deep fungal infections of the skin caused by dermatophytes (fungi). Specifically, in an animal model, Friedman’s research team found that sustained NO facilitated a quicker, more impactful response to treatment over the commercially available topical terbinafine, showing 95 percent infection clearance by the third day of treatment.
NITRIC OXIDE FOR THE TREATMENT OF ACNE
The Pharmaceutical Journal interviews Dr. Adam Friedman about his perspective on new acne treatments, including the promise of Nitric Oxide loaded into sustainably delivered nanoparticles in an article title, “Innovation in acne treatment is long overdue but the treatment pipeline looks promising” 25 OCT 2017
"GET TO KNOW NO: DECONSTRUCTING THE DATA ON NITRIC OXIDE–RELEASING TECHNOLOGIES FOR ACNE"
In Cutis, presented by MDedge, Dr. Adam Friedman discusses the advantages that NO-generating systems, like Zylö’s Z-pod™ platform, have over NO-donor systems, like Novan’s.
Z-PODS USED TO PREVENT INFLAMMATORY ACNE THROUGH SLOW-RELEASED NITRIC OXIDE
In Science Daily, Adam Friedman M.D. discusses how NO-releasing particles can be used to more effectively treat acne, especially through its anti-inflammatory mechanisms.
"HARNESSING THE POWER OF NANOTECHNOLOGY TO TREAT INFECTIONS"
In Practical Dermatology’s Physician Spotlight, Dr. Adam Friedman discusses how Zylö’s Z-pods™ can harness the power of Nitric Oxide and other payloads to treat infections.
NITRIC OXIDE TO TREAT ERECTILE DYSFUNCTION
In Nanowerk’s ‘Spotlight’ feature, called “A nanoparticle-based alternative to Viagra,” exciting new research is reviewed. The research results were published in The Journal of Sexual Medicine "Topically Applied NO-Releasing Particles Can Increase Intracorporal Pressure and Elicit Spontaneous Erections in a Rat Model of Radical Prostatectomy" from an interdisciplinary team of researchers at Einstein College of Medicine and UCSD.
"INFLAMMATORY ACNE: NEW DEVELOPMENTS IN PATHOGENESIS AND TREATMENT"
In the “COMMENTARY” section of Cutis, Dr. Adam Friedman and Jamie Rosen discuss new data that suggest inflammation is the inciting factor in acne.
"HEALING WOUNDS WITH ANTIMICROBIAL CURCUMIN NANOPARTICLES"
In Genesis Nanotechnology, Adam Friedman M.D. discusses how Zylö’s curcumin-loaded Z-pods™ represent the symbiosis of ancient wisdom with modern medical science.
NITRIC OXIDE ACCELERATES/IMPROVES HEALING OF BURN WOUNDS
An InterNano article discusses the recently published work titled, "N-acetylcysteine S-nitrosothiol Nanoparticles Prevent Wound Expansion and Accelerate Wound Closure in a Murine Burn Model" from the Journal of Drugs in Dermatology and describes how Nitric Oxide can be an effective treatment of burns.