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Nitric Oxide Z-pods™ for Infectious Diseases / Inflammatory Skin Disease / SSTIs

  • Caroline B. Costa-Orlandi PhD, Breanne Mordorski BA, Ludmila M. Baltazar PhD, Maria José S. Mendes-Giannini PhD, Joel M. Friedman MD PhD, Joshua D. Nosanchuk MD, Adam J. Friedman MD "Nitric-Oxide Releasing Nanoparticles as a Strategy to Improve Current Onychomycosis Treatments” J. of Drugs in Dermatology, July 2018 | Volume 17 | Issue 7 | Original Article | 717 | [Read Publication] 

  • Qin M, Landriscina A, Rosen J, Wei G, Kao S, Olcott W, Agak GW, Paz KB, Bonventre J, Clendaniel A, Harper S, Adler B, Krausz A, Friedman J, Nosanchuk J, Kim J, Friedman AJ. "Nitric Oxide Releasing Nanoparticles Prevent Propionibacterium Acnes Induced Inflammation by both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response" J Invest Dermatol. 2015;135(11):2723-31.

  • Landriscina A, Rosen J, Friedman AJ. "Biodegradable chitosan nanoparticles in drug delivery for infectious disease" Nanomedicine (Lond). 2015;10(10):1609-19.

  • Landriscina A, Rosen J, Blecher-Paz K, Long L, Ghannoum M, Nosanchuk J, Friedman AJ. "Nitric oxide-releasing nanoparticles as a treatment for cutaneous dermatophyte infections" Sci Lett 2015, 4: 193

  • Baltazar LM, Karusz AE, Souza AC, Adler B, Landriscina A, Musaev T, Nosanchuk JD, Friedman AJ. "Trichophyton rubrum is inhibited by free and nanoparticle encapsulated curcumin by induction of nitrosative stress after photodynamic activation" PLoS ONE 10(3): e0120179. doi:10.1371/journal. pone.0120179

  • Mordorski B, Pelgrift R, Krausz A, Adler B, Batista A, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Nacharaju P, Friedman AJ.   "S-nitrosocaptopril Nanoparticles as Nitric Oxide-Liberating and Transnitrosylating Anti-infective Technology" Nanomedicine (in press). 

  • Krausz AE, Adler BL, Cabral V, Navati MH, Doemer J, Charafeddine R, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ.
    "Curcumin-Encapsulated Nanoparticles as an Innovative Antimicrobial and Wound Healing Agent" Nanomedicine  2014 Sep 16. pii: S1549-9634(14)00527-9. doi: 10.1016/j.Nano.2014.09.004. [Epub ahead of print].

  • Sanchez, D, Schairer, D, Tuckman-Vernon, C, Chouake, C, Kutner, A, Makdisi J, Friedman, J, Nosanchuk J, Friedman, A. "Amphotericin B Releasing Nanoparticle Topical Treatment of Candida in the Setting of a Burn Wound"  Nanomedicine 2014;10(1):269-77.

  • Kutner, A and Friedman A.  Use of Nitric Oxide nanoparticles for the Treatment of Skin and Soft Tissue Infections.  WIRE's Nanomed Nanobiotechnology 2013. doi: 10.1002/wnan.1230

  • Pelgrift, R, and Friedman, A.   "Nanotechnology as a Therapeutic Tool to Combat Microbial Resistance." Adv Drug Deliv Rev. 2013 Jul 24.  doi:pii: S0169-409X(13)00165-8.

  • Kutner, A and Friedman, A.   "Current Trends in Topical Antimicrobials." J Drugs Dermatol. 2013; 12(1): 122-126.

  • Schairer, D, Martinez, L, Blecher, K, Chouake, J, Nacharaju, P, Gialanella, P, Friedman J, Nosanchuk, J, Friedman, A. "Nitric Oxide Nanoparticles: Pre-clinical Utility as a Therapeutic for Intramuscular Abscesses."  Virulence 2012; 3(1):1-6.

  • Marcherla, C, Sanchez, DA, Ahmadi, M, Vellozi, EM, Friedman, AJ, Nosanchuk, JD, Martinez, LR.
    "Nitric Oxide-Releasing Nanoparticles for the Treatment of Candida albicans Burn Infections." Front. Microbio. 2012;3:193. [Epub 2012 Jun 8.] 

  • Chouake, J, Schairer, D, Kutner, A, Sanchez, D, Makdisi, J, Blecher-Paz, K, Nacharaju, P, Tuckman-Vernon, C, Gialanella, P, Friedman, JM, Nosanchuk, JD, Friedman, A.
    "Nitrosoglutathione Generating Nitric Oxide Nanoparticles as an Improved Strategy for Combating Pseudomonas Aeruginosa - Infected Wounds." J Drugs Dermatol. 2012; 11(12):1471-1477. 

  • Schairer, D, Chouake, J, Nosanchuk, JD, Friedman, A. "The Potential of Nitric Oxide-Releasing Therapies as Antimicrobial Agents." Virulence. 2012; 3(3): 1-9. 

  • Friedman, A, Blecher, K, Schairer, D, Tuckman-Vernon, C, Nacharaju, P, Sanchez, D, Gialanelll, P, Martinez, L, Friedman, J, and Nosanchuk, J. "Improved Antimicrobial Efficacy with Nitric Oxide-Releasing Nanoparticle Generated S-Nitrosoglutathione." Nitric Oxide. 2011; 25: 381-386.

  • Friedman, A, Blecher, K, Sanchez, D, Tuckman-Vernon, C, Gialanella, P, Friedman, JM, Martinez, L, Nosanchuk, J. "Susceptibility of Gram Positive and Negative Bacteria to Novel Nitric Oxide-Releasing Nanoparticle Technology." Virulence. 2011; 2(3). 217-21. 

  • Englander, L, and Friedman, A.  "Nitric Oxide Nanoparticle Technology: A Novel Antimicrobial Agent in the Context of Current Treatments for Skin and Soft Tissue Infections." J Clin Aesth Dermatol. 2010; 3(6): 45-50. 

  • Han, G, Martinez, LM, Mihu, MR, Friedman, A, Friedman, JM, Nosanchuk, J.
    "Nitric Oxide-Releasing Nanoparticles are Therapeutic for Staphylococcus aureus Abscesses in Murine Model of Infection." PLoS ONE 2009; 4(11): e7804.


Nitric Oxide Z-pods™ for Nail Fungus

  • Mordorski B, Costa-Orlandi C, Balthazar L, Carreño L, Landriscina A, Rosen J, Navati M, Mendes-Giannini M, Friedman J, Nosanchuk J, Friedman A, "Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubric dermatophytosis." nanomedicine: Nanotechnology, Biology, and Medicine 2017.06 


Nitric Oxide Z-pods™ for Wound Healing

  • Landriscina A, Musaev T, Rosen J, Ray A, Nacharaju P, Nosanchuk JD, Friedman AJ. N-acetylcysteine S-nitrosothiol Nanoparticles Prevent Wound Expansion and Accelerate Wound Closure in a Murine Burn Model. J Drugs Dermatol. 2015. 4(7):726-732.

  • Charafeddine RA, Makdisi J, Schairer D, O'Rourke BP, Diaz-Valencia JD, Chouake J, Kutner A, Krausz A, Adler B, Nacharaju P, Liang H, Mukherjee S, Friedman JM, Friedman A, Nosanchuk JD, Sharp DJ. Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing. J Invest Dermatol. 2015;135(9):2309-18.

  • Kutner, A, and Friedman, A.  Nitric Oxide Nanoparticles for Wound Healing: Future Directions to Overcome Challenges. Expert Review of Dermatology. 2013; 8(5): 451-461. 

  • Blecher, K Martinez, LR, Tuckman-Vernon, C, Nacharaju, P, Schairer, D, Chouake, J, Friedman, JM, Alfieri, A, Guha, C, Nosanchuk, JD, Friedman, A. Nitric Oxide-Releasing Nanoparticles Accelerate Wound Healing in NOD-SCID Mice. Nanomedicine.2012;8(8):1364-71. 

  • Han G, Nguyen LN, Macherla C, Chi Y, Friedman JM, Nosanchuk JD, Martinez, LR.
    Nitric Oxide-Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition. Am J Pathol. 2012; 180 (4):1465-73. 


Z-pods™ for siRNA Delivery

  • Austin TO, Matamoros AJ, Friedman JM, Friedman AJ, Nacharaju P, Yu W, Sharp DJ & Baas PW “Nanoparticle Delivery of Fidgetin siRNA as a Microtubule-based Therapy to Augment Nerve Regeneration.” Scientific Reports 7, Article number: 9675(2017) doi:10.1038/s41598-017-10250-z


Curcumin Z-pods™ for Osteoarthritis

  • Zhuo Zhang1,2,3†, Daniel J. Leong1,2†, Lin Xu1,2, Zhiyong He1,2, Angela Wang1,2, Mahantesh Navati4,5, Sun J. Kim1, David M. Hirsh1, John A. Hardin1, Neil J. Cobelli1, Joel M. Friedman4,5 and Hui B. Sun1,2* Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model.  Arthritis Research & Therapy (2016) 18:128


Nitric Oxide Z-pods™ for Vascular Dysfunction

  • Nacharaju, P, Friedman, AJ, Friedman, JM, Cabrales, P.  Exogenous Nitric Oxide Prevents Collapse during Hemorrhagic Shock. Resuscitation. 2011; 82(5):607-13. 

  • Cabrales, P, Han, G, Nacharaju, P, Friedman, AJ, Friedman, JM.  Reversal of Hemoglobin-Induced Vasoconstriction with Sustained Release of Nitric Oxide.  Am J Physiol Heart Circ Physiol. 2011; 300(1):H49-56. 

  • Nacharaju, P., Tuckman-Vernon, C., Maier, K. E., Chouake, J., Friedman, A., Cabrales, P., and Friedman, J. M.  A Nanoparticle Delivery Vehicle for S-nitroso-N-acetyl Cysteine: Sustained Vascular Response.  Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society 2012; 27, 150-160 


Nitric Oxide Z-pods™ for Erectile Dysfunction

  • Moses T Tar, Joel M Friedman, Andrew Draganski, Kelvin P Davies. Topically delivered nitric oxide acts synergistically with an orally administered PDE5 inhibitor in eliciting an erectile response in a rat model of radical prostatectomy, International Journal of Impotence Research, 2021 May 20 doi: 10.1038/s41443-021-00451-6, PMID: 34017115

  • Andrew Draganski, PhD,Moses T. Tar, MD,Guillermo Villegas, PhD,Joel M. Friedman, MD, PhD,and Kelvin P. Davies, MSc, PhD.Topically Applied Curcumin-Loaded Nanoparticles Treat Erectile Dysfunction in a Rat Model of Type-2 Diabetes, J. of Sexual Medicine 2018;15:645e653

  • Tar M, Cabrales P, Navati M, Adler B, Nacharaju P, Friedman A, Friedman J, Davies K. Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy. J Sex Med. 2014;11(12):2903- 14 

  • Han, G, Tar, M, Dwarakka, K, Friedman, A, Melman, A, Friedman, JM, Davies, KP.  Nanoparticles as a Novel Delivery Vehicle for Therapeutics Targeting Erectile Dysfunction. J Sexu Med. 2010; 7(1 Pt 1):224-33. 


Nitric Oxide Z-pods™ for Sinusitis

  • Waleed M. Abuzeid MD, Vallerinteavide Mavelli Girish PhD, Judd H. Fastenberg MD, Andrew R. Draganski PhD, Andrew Y. Lee MD, Joshua D. Nosanchuk MD, Joel M. Friedman MD, PhD Nitric oxide‐releasing microparticles as a potent antimicrobial therapeutic against chronic rhinosinusitis bacterial isolates Allergy & Rhinology 2018-07-25. [Read Publication] 


Z-pod™ Platform Characterization

  • Krausz AE, Adler BL, Cabral V, Navati MH, Doemer J, Charafeddine R, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ. Curcumin- encapsulated nanoparticles as an innovative antimicrobial and wound healing agent. Nanomedicine. 2015;11(1):195-206.

  • Sanchez, D, Schairer, D, Tuckman-Vernon, C, Chouake, C, Kutner, A, Makdisi J(1-3), Friedman, J, Nosanchuk, A.J, Friedman, A. Amphotericin B Releasing Nanoparticle Topical Treatment of Candida in the Setting of a Burn Wound. Nanomedicine. 2014; 10(1):269-77.

  • Han, G, Friedman, A, Friedman, JM. Nitric Oxide-Releasing Nanoparticle Synthesis and Characterization. Nitric Oxide: Methods in Molecular Biology,  2011, Volume 704, Part 2, 187-195.

  • Cabrales, P, Friedman A, Friedman, J.  Nitric Oxide from Nanoparticles and Applications to Cardiovascular Health. Nanomedicine and the Cardiovascular System, Ed: Hunter R and Preedy V, CRC Press. 2011.

  • Han, G, Tar, M, Dwarakka, K, Friedman, A, Melman, A, Friedman, JM, Davies, KP. Nanoparticles as a Novel Delivery Vehicle for Therapeutics Targeting Erectile Dysfunction. J Sexu Med. 2010; 7(1 Pt 1):224-33. 

  • Cabrales, P, Han, G, Roche C, Nacharaju, P, Friedman, A, Friedman, J. Sustained-Release Nitric Oxide from Long-Lived Circulation Nanoparticles. Free Rad Med. 2010; 15;49(4):530-8.

  • Navati, M. S., and Friedman, J. M.  Glass Matrix-Facilitated Thermal Reduction: A Tool for Probing Reactions of met Hemoglobin with Nitrite and Nitric Oxide. J Phys Chem B. 2010; 114, 2938-2943 

  • Friedman A, Han G, Navati MH, Chacko M, Gunther L, Alfieri A, Friedman JM.  Sustained-Release Nitric Oxide Releasing Nanoparticles: Characterization of a Novel Platform Based on Nitrite Containing Hydrogel/Glass Composites. Nitric Oxide 2008; 19(1): 12-20. 

  • Navati, M. S., and Friedman, J. M. Sugar-derived Glasses Support Thermal and Photo-Initiated Electron Transfer Processes Over Macroscopic Distances. The Journal of Biological Chemistry 2006; 281, 36021-36028